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MKULTRA (also known as MK-ULTRA) was the code name for a CIA mind control research program lasting from the 1950s through the 1970s. The project's goal was to produce a perfect truth drug for use in interrogating suspected Soviet spies during the Cold War, and generally to explore any other possibilities of mind control. Experiments were often conducted without the subjects' knowledge or consent. The project was headed by Dr. Sydney Gottlieb.

Certain drugs were used on subjects to try and put them in a state where they would have no problem revealing information. Drugs included narcotics, barbituates, amphetamines and LSD. None of them were particularly successful as truth serum or mind control.


  • Martin A. Lee, and Bruce Shlain, Acid Dreams: The CIA, LSD, and the Sixties Rebellion. New York: Grove Press, 1985. 343 pages.
  • John Marks, The Search for the "Manchurian Candidate": The CIA and Mind Control. New York: McGraw-Hill Paperback Edition, 1980. 242 pages.

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